Hydrochloric Acid → N-[4-(hexadecylamino)benzoyl]-2-aminoethanesulfonic acid

HRID 2163789

반응식

HRID 2163789 반응식
[NH2:1][CH2:2][CH2:3][S:4]([OH:7])(=[O:6])=[O:5].FC(F)(F)C([N:12]([C:29]1[CH:44]=[CH:43][C:32]([C:33](ON2C(=O)CCC2=O)=[O:34])=[CH:31][CH:30]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=O.[OH-].[Na+].Cl>O.C(O)C.C(N(CC)CC)C>[CH2:13]([NH:12][C:29]1[CH:30]=[CH:31][C:32]([C:33]([NH:1][CH2:2][CH2:3][S:4]([OH:7])(=[O:6])=[O:5])=[O:34])=[CH:43][CH:44]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 1123TaurineHCID 14798Sodium HydroxideHCID 20437360N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide

생성물 1

HCID 20437369N-[4-(hexadecylamino)benzoyl]-2-aminoethanesulfonic acid

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매2회HCID 8471Triethylamine용매

실험 절차

To a stirred solution of 2.50 g. of taurine and 5.6 ml. of triethylamine in 22.5 ml. of water is added 5.55 g. of N-[p-(2,2,2-trifluoro-N-hexadecylacetamido)benzoyloxy]succinimide as a solution in 45 ml. of ethanol. After 24 hours, the mixture is treated with 20 ml. of 2.0M sodium hydroxide and 25 ml. of water. After stirring for 10 min., the mixture is acidified with dilute hydrochloric acid, and the crude product is collected by filtration. Recrystallization affords the title compound as a white solid, m.p. 190°-220° C.

후처리

  1. additionthe mixture is treated with 20 ml
  2. filtrationthe crude product is collected by filtration
  3. customRecrystallization

출처 및 근거

ORD 기록
ord-f377ed7c16e14487b3f13d1ce25884d8
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04136256

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