반응식
F[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].Cl.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[F:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:3]=1[C:4]#[N:5]참가 물질
4
실험 절차
A mixture of 2.8 g (20 mmol) of 2,6-difluorobenzonitrile in 20 ml of aniline is refluxed for 6 hrs. The mixture is poured into diluted HCl and the acid is extracted with methylene chloride. Evaporation gives the crude product which is chromatographed on silica gel (50% hexane--CH2Cl2) to give the title compound, m.p. 97°-99° C.
후처리
- temperatureis refluxed for 6 hrs
- extractionthe acid is extracted with methylene chloride
- customEvaporation
- customgives the crude product which
- customis chromatographed on silica gel (50% hexane--CH2Cl2)
출처 및 근거
- ORD 기록
- ord-30c1ed890d374469b34a85c512485c68
- 출처 데이터셋
- uspto-grants-1985_03
- 특허 번호
- US04504660
연결된 노트
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