홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → HCID 86739454, 화합물

HRID 2164572
노트
인쇄 미리보기

반응식

HRID 2164572 반응식
C[O:2][C:3](=[O:38])[C@H:4]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[NH:5][C:6](=[O:30])[C@H:7]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH:27]=[CH2:28])=[C:21]([Cl:29])[CH:20]=1)[NH:8][C:9](=[O:17])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[OH-].[Na+].Cl>CC(C)=O>[CH2:26]([O:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:18][C@@H:7]([C:6]([NH:5][C@H:4]([C:3]([OH:38])=[O:2])[CH2:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)=[O:30])[NH:8][C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:20][C:21]=1[Cl:29])[CH:27]=[CH2:28]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70486802HCID 70486802, 화합물

생성물 1

HCID 86739454HCID 86739454, 화합물수율 52.3%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
0 °C

실험 절차

4-Allyloxy-3-chloro-phenylacetyl-(L)-phenylalanyl-(L)-phenylalanine methyl ester (5.3 g) was suspended in acetone (40 ml) to which was added aqueous sodium hydroxide (1M, 20.0 ml) and the whole was heated to effect solution. After the solution had been cooled to 0° C., the pH was adjusted to 2-3 using aqueous hydrochloric acid (3M) and the whole was extracted with ethyl acetate (80 ml). The extract was dried (anhydrous sodium sulphate) and the solvent was evaporated at reduced pressure to leave a small volume of material. Light petroleum (b.p. 80°-100° C.) was added to precipitate the solid (3.5 g) of m.p. 180°-186° C. After recrystallisation from ethyl acetate/light petroleum (b.p. 80°-100° C.), the above-named product (2.7 g), m.p. 183°-186° C., was obtained.

후처리

  1. temperaturethe whole was heated
  2. extractionthe whole was extracted with ethyl acetate (80 ml)
  3. dry with materialThe extract was dried (anhydrous sodium sulphate)
  4. customthe solvent was evaporated at reduced pressure
  5. customto leave a small volume of material
  6. customto precipitate the solid (3.5 g) of m.p. 180°-186° C
  7. customAfter recrystallisation from ethyl acetate/light petroleum (b.p. 80°-100° C.)

출처 및 근거

ORD 기록
ord-64d6a60fcbdc4cd8a57d5eaec0e60cda
출처 데이터셋
uspto-grants-1985_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04505898

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트