Hydrochloric Acid → 6-Allyloxybenzothiazole-2-sulfonamide

HRID 2164615노트

반응식

HRID 2164615 반응식
CN(C)C=[N:4][S:5]([C:8]1[S:9][C:10]2[CH:16]=[C:15]([O:17][CH2:18][CH:19]=[CH2:20])[CH:14]=[CH:13][C:11]=2[N:12]=1)(=[O:7])=[O:6].[OH-].[Na+].O.Cl>CO>[CH2:18]([O:17][C:15]1[CH:14]=[CH:13][C:11]2[N:12]=[C:8]([S:5]([NH2:4])(=[O:7])=[O:6])[S:9][C:10]=2[CH:16]=1)[CH:19]=[CH2:20]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 53647804N,N-Dimethyl-N'-(6-allyloxybenzothiazole-2-sulfonyl)formamidine

생성물 1

HCID 134732046-Allyloxybenzothiazole-2-sulfonamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

A solution of product from Step B (0.45 gm, 1.4 mmol) in methanol (1.5 mL) was added to 2N sodium hydroxide (2 mL) and stirred at 40° C. for 1 hour. The reaction was poured into water, acidified (HCl), and the product extracted into ethyl acetate. The extract was dried (Na2SO4) and evaporated to give crude product. Upon trituration of this residue with methylene chloride, the product precipitated and was collected (0.18 gm) and shown to be identical with the product of Example 1.

후처리

  1. extractionthe product extracted into ethyl acetate
  2. dry with materialThe extract was dried (Na2SO4)
  3. customevaporated
  4. customto give crude product
  5. customUpon trituration of this residue with methylene chloride, the product precipitated
  6. customwas collected (0.18 gm)

출처 및 근거

ORD 기록
ord-5581e90325654ed8a600846d876b58ed
출처 데이터셋
uspto-grants-1985_03
특허 번호
US04505923

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