Diisopropylethylamine → HCID 23043521, 화합물

HRID 2165043노트

반응식

HRID 2165043 반응식
[NH2:1][CH2:2][CH2:3][NH:4][C:5](=[O:13])[CH2:6][N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12].Br[CH2:15][CH2:16][Si:17]([CH2:20][CH2:21]Br)([CH3:19])[CH3:18].CCN(C(C)C)C(C)C>C(Cl)(Cl)Cl>[CH3:18][Si:17]1([CH3:19])[CH2:20][CH2:21][N:1]([CH2:2][CH2:3][NH:4][C:5](=[O:13])[CH2:6][N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:15][CH2:16]1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 12169348Bis(2-bromoethyl)(dimethyl)silaneHCID 19908624HCID 19908624, 화합물

생성물 1

HCID 23043521HCID 23043521, 화합물수율 15%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 1.90 g (10.3 mmol) of N-(2-aminoethyl)-2-oxo-1-pyrrolidineacetamide, 2.76 g (10.1 mmol) of bis(2-bromoethyl)dimethylsilane, 5.20 g of Huenig base, and 20 ml of chloroform was stirred and then the solvent was removed in vacuo. The resulting mixture was heated at 100°-105° C. for 8 hours. Aqueous NaHCO3 was added to the cooled reaction mixture, and the aqueous solution was extracted with chloroform. The dried chloroform solution was concentrated in vacuo and chromatographed on silica gel column to afford 450 mg (Yield: 15.0%) of the desired compound.

후처리

  1. customthe solvent was removed in vacuo
  2. temperatureThe resulting mixture was heated at 100°-105° C. for 8 hours
  3. additionAqueous NaHCO3 was added to the cooled reaction mixture
  4. extractionthe aqueous solution was extracted with chloroform
  5. concentrationThe dried chloroform solution was concentrated in vacuo
  6. customchromatographed on silica gel column

출처 및 근거

ORD 기록
ord-2e8b07e7f01d404396ceb0de31adc2bc
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939126

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