Benzaldehyde → 2-Propen-1-one,1-(5-methyl-2-thienyl)-3-phenyl-

HRID 2165128

반응식

HRID 2165128 반응식
[OH-].[Na+].[C:3]([C:6]1[S:7][C:8]([CH3:11])=[CH:9][CH:10]=1)(=[O:5])[CH3:4].[CH:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.Cl>C(O)C>[CH3:11][C:8]1[S:7][C:6]([C:3](=[O:5])[CH:4]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:10][CH:9]=1

참가 물질

6

반응물 4

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 836552-Acetyl-5-methylthiophene

생성물 1

HCID 2386072-Propen-1-one,1-(5-methyl-2-thienyl)-3-phenyl-수율 67.2%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A stirred solution of 2.2 grams (0.055 mole) of sodium hydroxide in 20 ml of ethanol was cooled to 0° C. and a mixture of 4.0 grams (0.03 mole) of 2-acetyl-5-methylthiophene and 3.1 grams (0.03 mole) of benzaldehyde in 5 ml of ethanol was added dropwise. Upon completion of addition the reaction mixture was allowed to warm to ambient temperature where it stirred for 16 hours. The reaction mixture was poured into aqueous 1N hydrochloric acid and extracted with methylene chloride. The extract was dried with sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to yield 4.6 grams of 1-(5-methyl-2-thienyl)-3-phenyl-2-propen-1-one as a solid.

후처리

  1. additionwas added dropwise
  2. additionUpon completion of addition the reaction mixture
  3. extractionextracted with methylene chloride
  4. dry with materialThe extract was dried with sodium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-70d25324e4b141e2a8305046095b2240
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04939165

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