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Hydrochloric Acid → HCID 53907172, 화합물

HRID 2165749
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HRID 2165749 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([CH3:23])([CH3:22])[C:10](=[O:21])[C:11]([N:16]2[CH:20]=[N:19][CH:18]=[N:17]2)=[CH:12][CH2:13][CH2:14][CH3:15])=[CH:4][CH:3]=1.[BH4-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([CH3:22])([CH3:23])[CH:10]([OH:21])[C:11]([N:16]2[CH:20]=[N:19][CH:18]=[N:17]2)=[CH:12][CH2:13][CH2:14][CH3:15])=[CH:4][CH:3]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 54324090HCID 54324090, 화합물

생성물 1

HCID 53907172HCID 53907172, 화합물수율 92.9%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
0 °C

실험 절차

7 g (0.021 mol) of 1-(4-chlorophenyl)-2,2-dimethyl-4-(1,2,4-triazol-1-yl)-4-octen-3-one (Example 1) are dissolved in 100 ml of methanol, and a solution of 0.21 g (0.006 mol) of sodium borohydride in 5 ml of icewater is added dropwise at -10° C. The reaction mixture is subsequently stirred at 0° C. for 1.5 hours and is then adjusted to a pH value of 6 to 7 with dilute hydrochloric acid. The reaction mixture is concentrated by distilling off the solvent in vacuo. The residue is taken up in chloroform and the mixture is washed with water, dried over sodium sulphate and concentrated. 6.5 g (92.9% of theory) of 1-(4-chlorophenyl)-2,2-dimethyl-4-(1,2,4-triazol-1-yl)-4-octen-3-ol of refractive index nD20 1.5383 are obtained.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. distillationby distilling off the solvent in vacuo
  3. washthe mixture is washed with water
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bd79ea6fd33b4c99a1cb7e7b45862fb8
출처 데이터셋
uspto-grants-1990_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04940798

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