1,5-Pentanediol, 1,5-dimethanesulfonate → 1-Hexadecyloxy-3-[5-(methanesulfonyloxy)pentyloxy]-2-methylenepropane

HRID 2166429

반응식

HRID 2166429 반응식
[CH2:1]([O:17][CH2:18][C:19](=[CH2:22])[CH2:20][OH:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[H-].[Na+].[CH3:25][S:26]([O:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]OS(C)(=O)=O)(=[O:28])=[O:27]>CN(C)C=O>[CH2:1]([O:17][CH2:18][C:19](=[CH2:22])[CH2:20][O:21][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][O:29][S:26]([CH3:25])(=[O:28])=[O:27])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

5

반응물 3

HCID 169201,5-Pentanediol, 1,5-dimethanesulfonateHCID 24758Sodium hydrideHCID 113588863-Hexadecyloxy-2-methylenepropan-1-ol

생성물 1

HCID 230395961-Hexadecyloxy-3-[5-(methanesulfonyloxy)pentyloxy]-2-methylenepropane

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
54 °C

실험 절차

3-Hexadecyloxy-2-methylenepropan-1-ol (from Preparation 1) (4.45 g), sodium hydride dispersion (55-60% in oil, 1.4 g), and 1,5-dimethanesulfonyloxypentane (10.9 g) were mixed in dry dimethylformamide (33 ml) and stirred at 54° C. for 20 hours. Following the work-up procedure described in Preparation 7, the desired product was obtained.

후처리

  1. customdescribed in Preparation 7

출처 및 근거

ORD 기록
ord-c5158f21fbb643de986a729d7be71e49
출처 데이터셋
uspto-grants-1990_07
특허 번호
US04945098

연결된 노트

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