Sodium hydride → Mannitol

반응식

C(O)[CH:2]([OH:13])[CH:3]([OH:12])[CH:4]([OH:11])[CH:5]([OH:10])[CH:6]([OH:9])[CH:7]=[O:8].[H-].[Na+]>C(COC)OC>[CH2:2]([OH:13])[C@H:3]([C@H:4]([C@@H:5]([C@@H:6]([CH2:7][OH:8])[OH:9])[OH:10])[OH:11])[OH:12]

참가 물질

실험 절차

In Method B, 3,6-anhydro-2-deoxy-4,5,7-tris-O-(phenylmethyl)-D-gluco (and D-manno) heptose mixture 4 is reacted with a tetrasubstituted bisphosphonate, where and R' and R" may be any of the aliphatic substituents listed in Table II, and sodium hydride in dimethoxy ethane, giving the isomeric mixture 2,5-anhydro-1-deoxy-1-C-(disubstituted phosphinyl)-3,4,6-tris-O-(phenylmethyl)-D-glucitol and D-mannitol 12' which are then reacted as described in Method A giving 2,5-anhydro-1-deoxy 1-(disubstituted phosphinyl)-D-mannitol, 6-(disubstituted phosphate) 14' and the corresponding D-glucitol derivative 23'. ##STR16##