Ethanol → 4-p-Tolylsulfonyl-4-methyl-3-dimethoxymethyl-pentanoic acid

HRID 2166957

반응식

HRID 2166957 반응식
[C:1]1([CH3:24])[CH:6]=[CH:5][C:4]([S:7]([C:10]([CH3:23])([CH3:22])[CH:11]([CH:17]([O:20][CH3:21])[O:18][CH3:19])[CH2:12][C:13]([O:15]C)=[O:14])(=[O:9])=[O:8])=[CH:3][CH:2]=1.C(O)C.[OH-].[Na+]>O>[C:1]1([CH3:24])[CH:6]=[CH:5][C:4]([S:7]([C:10]([CH3:22])([CH3:23])[CH:11]([CH:17]([O:18][CH3:19])[O:20][CH3:21])[CH2:12][C:13]([OH:15])=[O:14])(=[O:9])=[O:8])=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 12850320Methyl 4-p-tolylsulfonyl-4-methyl-3-dimethoxymethylpentanoate

생성물 1

HCID 128503174-p-Tolylsulfonyl-4-methyl-3-dimethoxymethyl-pentanoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1 g of the product of Step A was added to a mixture of 20 ml of ethanol and 20 ml of aqueous 2 N sodium hydroxide solution and the mixture was refluxed for 17 hours and was cooled and poured into water. The mixture was extracted with methylene chloride and the organic phase was evaporated to dryness to obtain 4-p-tolylsulfonyl-4-methyl-3-dimethoxymethyl-pentanoic acid.

후처리

  1. temperaturethe mixture was refluxed for 17 hours
  2. temperaturewas cooled
  3. extractionThe mixture was extracted with methylene chloride
  4. customthe organic phase was evaporated to dryness

출처 및 근거

ORD 기록
ord-1f8589769f9842c4948589fc9c8644e6
출처 데이터셋
uspto-grants-1983_06
특허 번호
US04390724

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