Bromine → HCID 90185062, 화합물

HRID 2167697노트

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HRID 2167697 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:13])[C:10](=[O:12])[CH3:11])=[CH:5][CH:4]=1.[Br:16]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:16][CH2:11][C:10](=[O:12])[C:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:14])([F:15])[F:1])=[CH:8][CH:7]=1)=[O:13]

참가 물질

5

반응물 3

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 27776811-[4-(trifluoromethyl)phenyl]propane-1,2-dione

생성물 1

HCID 90185062HCID 90185062, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

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온도
70 °C

실험 절차

To a chloroform (6.0 mL) solution of 1-[4-(trifluoromethyl)phenyl]propane-1,2-dione (0.65 g), bromine (0.62 mL) was added, and the resultant was stirred at 70° C. for 6 hours. After standing to cool to room temperature, a 10% aqueous sodium thiosulfate solution was added thereto, followed by extraction with chloroform. An organic layer was separated using a phase separator, and the solvent was distilled off under reduced pressure to obtain the title compound (1.1 g) as a yellow oil.

후처리

  1. temperatureto cool to room temperature
  2. extractionfollowed by extraction with chloroform
  3. customAn organic layer was separated
  4. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-ddd1b302b77b4f358ebda7331f22eccf
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045466B2

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