Hydrochloric Acid → 3-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one

HRID 2168617

반응식

HRID 2168617 반응식
CO[C:3](=[O:19])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.C[Si](C)(C)[C:22]([F:25])([F:24])[F:23].[F-].[Cs+].Cl>C1COCC1>[CH2:12]([O:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][C:3](=[O:19])[C:22]([F:25])([F:24])[F:23])=[CH:10][CH:9]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 25953Cesium fluorideHCID 552549(Trifluoromethyl)trimethylsilaneHCID 2756645Methyl 2-(4-benzyloxyphenyl)acetate

생성물 1

HCID 673872073-(4-Benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of (4-benzyloxy-phenyl)-acetic acid methyl ester (11.7 mmol, 3.0 g), trimethyl-trifluoromethyl-silane and cesium fluoride in THF may be stirred at room temperature for 2 h. Hydrochloride may be added upon consumption of ester as indicated by TLC. The mixture may be stirred further at room temperature until the intermediate disappears as indicated by TLC to provide 3-(4-benzyloxy-phenyl)-1,1,1-trifluoro-propan-2-one.

후처리

  1. stirringThe mixture may be stirred further at room temperature until the intermediate

출처 및 근거

ORD 기록
ord-635bf373a0984232bca548a6e1588bee
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09045461B2

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