1-Octanethiol → 2-chloro-6-octylthiopyridine N-oxide

HRID 21694

반응식

HRID 21694 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N+:3]=1[O-:9].[CH2:10]([SH:18])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[OH-].[Na+]>CS(C)=O>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([S:18][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[N+:3]=1[O-:9]

참가 물질

5

반응물 3

HCID 81441-OctanethiolHCID 14798Sodium HydroxideHCID 8176732,6-Dichloropyridine N-Oxide

생성물 1

HCID 229063402-chloro-6-octylthiopyridine N-oxide

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

The 2.01 g (0.0122 moles) of 2,6-dichloropyridine N-oxide and 2.10 g (85%) (0.0122 moles) of 1-octylmercaptan was reacted with 0.488 g (0.0122 moles) of ground sodium hydroxide in 8.2 ml of DMSO at 80° C. for 6 hours to give 2-chloro-6-octylthiopyridine N-oxide. It was reacted with 1.47 g (0.0367 moles) of ground sodium hydroxide at 80° C. for 3 hours to give 1-hydroxy-6-octylthiopyridine-2(1H)-one. After cooling, it was added 180 ml of water and was adjusted with 6N HCL to pH 3. The precipitate was filtered, washed with water and washed with 150 ml of petroleum ether to give 1.34 g (43%).

출처 및 근거

ORD 기록
ord-d82bcb133ae44e5b85e75ac7761b2a1b
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424435

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