Methyl iodide → HCID 89580690, 화합물
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[CH2:9][CH2:10][OH:11])=[CH:4][CH:3]=1.[H-].[Na+].I[CH3:16]>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH2:9][CH2:10][O:11][CH3:16])[CH3:12])=[CH:6][CH:7]=1참가 물질
5
실험 절차
To the solution of 3-(4-bromophenyl)butan-1-ol (791 mg, 3.47 mmol) in tetrahydrofuran (50 mL) was added sodium hydride (278 mg, 6.94 mmol), the mixture was stirred at room temperature for 30 minutes, then iodomethane (985 mg, 6.94 mmol) was added, the mixture was stirred for 5 hours, then quenched with water (1 mL) concentrated and purified by column chromatography (silica gel, dichloromethane/methanol=20:1) to give 1-bromo-4-(4-methoxybutan-2-yl)benzene (541 mg, 64%).
후처리
- stirringthe mixture was stirred for 5 hours
- customquenched with water (1 mL)
- concentrationconcentrated
- custompurified by column chromatography (silica gel, dichloromethane/methanol=20:1)
출처 및 근거
- ORD 기록
- ord-b300e02efa034d78bd090fe070ca02c8
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09051269B2
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