Hydrochloric Acid → HCID 71075520, 화합물

HRID 2170709노트

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HRID 2170709 반응식
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([C@@H:11]([NH:13][C:14]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[N:21]([CH2:25][C:26]2[CH:27]=[C:28]([CH:36]=[CH:37][CH:38]=2)[O:29][C@@H:30]([CH3:35])[C:31]([O:33]C)=[O:32])[C:20]([CH3:39])=[C:19]3[CH3:40])=[O:15])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[Li+].[OH-].Cl>C1COCC1>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([C@@H:11]([NH:13][C:14]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[N:21]([CH2:25][C:26]2[CH:27]=[C:28]([CH:36]=[CH:37][CH:38]=2)[O:29][C@@H:30]([CH3:35])[C:31]([OH:33])=[O:32])[C:20]([CH3:39])=[C:19]3[CH3:40])=[O:15])[CH3:12])[CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 71075489HCID 71075489, 화합물

생성물 1

HCID 71075520HCID 71075520, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (S)-methyl 2-(3-((5(((S)-1-(3-isopropoxyphenyl)ethyl) carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoate (70 mg, 0.13 mmol, 1 equiv) in THF (2 mL) was added a 1 N LiOH aqueous solution of (1 mL). The reaction mixture was stirred 6 h at room temperature, then acidified with a 0.5 N HCl aqueous solution. The mixture was filtered and the precipate was dissolved in methanol and concentrated to obtain the crude product which was purified by prep. HPLC (MeOH/Acetonitrile/water 0.1% TFA) to obtain the title compound.

후처리

  1. filtrationThe mixture was filtered
  2. dissolutionthe precipate was dissolved in methanol
  3. concentrationconcentrated
  4. customto obtain the crude product which
  5. customwas purified by prep

출처 및 근거

ORD 기록
ord-b573e63655d04466ad0e409b19641a9d
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051265B2

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