Hydrochloric Acid → MFCD18873289

HRID 2170850노트

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HRID 2170850 반응식
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16]C)=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1.[OH-].[Na+].Cl>CO>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([OH:16])=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 671694841H-Indole-5-carboxylic acid, 1-(2-methoxyethyl)-, methyl ester

생성물 1

HCID 63750378MFCD18873289수율 95%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of methyl 1-(2-methoxyethyl)-1H-indole-5-carboxylate (132 mg, 0.57 mmol, Step-1), 2M aqueous sodium hydroxide solution (2 mL), and methanol (2 mL) was stirred at 60° C. for 2 hours. The mixture was acidified with 2M aqueous hydrochloric acid solution, and the organic solvent was concentrated under reduced pressure. The precipitate was collected by filtration and dried to give 118 mg (95%) of the title compound as a white solid.

후처리

  1. concentrationthe organic solvent was concentrated under reduced pressure
  2. filtrationThe precipitate was collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-9d1f213d501747d5a0db55da64284643
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051296B2

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