Bromine → 2-Amino-5-bromonicotinaldehyde hydrobromide
반응식
[Br:1]Br.[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>C(O)(=O)C>[BrH:1].[NH2:3][C:4]1[N:5]=[CH:6][C:7]([Br:1])=[CH:8][C:9]=1[CH:10]=[O:11]참가 물질
4
실험 절차
A solution of bromine (1.05 mL, 20.0 mmol) in acetic acid (20 mL) was added to a solution of 2-amino-3-pyridinecarboxaldehyde (2.5 g, 20 mmol) in acetic acid (50 mL) at room temperature. The reaction mixture was then stirred overnight. The resulting precipitate was filtered and washed with diethyl ether to give the title compound as a white solid (4.66 g, 80%).
후처리
- filtrationThe resulting precipitate was filtered
- washwashed with diethyl ether
출처 및 근거
- ORD 기록
- ord-004bfe9f392342fab47f97a990d27bd0
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09051321B2
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