Hydrochloric Acid → Methyl 2-(3-bromo-2-hydroxyphenyl)acetate

HRID 2173281노트

반응식

HRID 2173281 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10].C(NC(C)C)(C)C.C1C(=O)N([Br:27])C(=O)C1.Cl>C(Cl)Cl>[Br:27][C:7]1[C:2]([OH:1])=[C:3]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7912DiisopropylamineHCID 67184N-bromobutanimideHCID 89719Methyl (2-hydroxyphenyl)acetate

생성물 1

HCID 12159074Methyl 2-(3-bromo-2-hydroxyphenyl)acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a solution of methyl (2-hydroxyphenyl)acetate (14 g, 84.3 mmol) in 100 mL of DCM was added diisopropyl-amine (1.7 g, 16.8 mmol) and NBS (15 g, 84.2 mmol) at 0° C. The mixture was stirred at 0° C. for 1 h. The reaction was poured into 1N HCl, extracted with DCM, and concentrated to give crude methyl (3-bromo-2-hydroxyphenyl)acetate. Step C: methyl (3-bromo-2-methoxyphenyl)acetate

후처리

  1. extractionextracted with DCM
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0c1962e82cb44c15944798f6bb32a5e4
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056859B2

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