Hydrochloric Acid → 3-Amino-5-trifluoromethylpyrazine-2-carboxylic acid

HRID 2173735노트

반응식

HRID 2173735 반응식
C([O:3][C:4]([C:6]1[C:11]([NH2:12])=[N:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][N:7]=1)=[O:5])C.[OH-].[Na+].O.Cl>C(O)C>[NH2:12][C:11]1[C:6]([C:4]([OH:5])=[O:3])=[N:7][CH:8]=[C:9]([C:13]([F:16])([F:15])[F:14])[N:10]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 58442356HCID 58442356, 화합물2회

생성물 1

HCID 688182783-Amino-5-trifluoromethylpyrazine-2-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirring solution of 3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester (Intermediate 1) (0.5 g, 2.126 mmol) in dry ethanol (5 ml), 2M NaOH (5.32 ml, 10.63 mmol) was added. The yellow solution was stirred at RT. After 5 minutes, the reaction mixture was poured into water (15 ml) and the pH adjusted to pH 6 by addition of 1M HCl. The yellow precipitate formed was filtered under vacuum and dried to yield the title compound. 1H NMR (400 MHz, DMSO-d6) δ 13.65 (1H, s), 8.3 (1H, s), 7.86 (2H, br s)

후처리

  1. customThe yellow precipitate formed
  2. filtrationwas filtered under vacuum
  3. customdried

출처 및 근거

ORD 기록
ord-9dd4a7932a9f4e009c5cd52a8a840dc2
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056867B2

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