Br[C:2]1[C:3]([C:8]([CH3:12])([CH3:11])[C:9]#[N:10])=[N:4][CH:5]=[CH:6][CH:7]=1.[F:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:23]=1[N:22]=[CH:21][C:20]([OH:24])=[CH:19]2.C(=O)([O-])[O-].[Cs+].[Cs+].C(CC(=O)C(C)(C)C)(=O)C(C)(C)C>CN1CCCC1=O.[Cu]Cl>[F:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:23]=1[N:22]=[CH:21][C:20]([O:24][C:2]1[C:3]([C:8]([CH3:12])([CH3:11])[C:9]#[N:10])=[N:4][CH:5]=[CH:6][CH:7]=1)=[CH:19]21.35 g of 2-(3-bromo-pyridin-2-yl)-2-methyl-propionitrile were dissolved in 6 ml of N-methylpyrrolidone. 0.82 g of 8-fluoro-3-hydroxyquinoline, 1.95 g of cesium carbonate, 0.18 g of dipivaloylmethane and 0.50 g of copper (I) chloride were added thereto followed by stirring for 23 hours at 130° C. Subsequently, the reaction mixture was cooled to room temperature and purified by silica gel column chromatography to obtain 0.46 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methylpropionitrile.
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