Water → Nicardipine

HRID 2174261

반응식

HRID 2174261 반응식
[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][CH2:12][CH2:13][N:14]([CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH3:15])=[O:10])[CH:4]([C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([N+:29]([O-:31])=[O:30])[CH:28]=2)[C:3]=1[C:32]([O:34][CH3:35])=[O:33].Cl.O.[OH-].[Na+]>C(OC(=O)C)C>[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][CH2:12][CH2:13][N:14]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH3:15])=[O:10])[CH:4]([C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([N+:29]([O-:31])=[O:30])[CH:28]=2)[C:3]=1[C:32]([O:34][CH3:35])=[O:33]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 41114Nicardipine Hydrochloride

생성물 1

HCID 4474Nicardipine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Nicardipine (free base) was prepared by mixing nicardipine-HCl (Sigma-Aldrich, St. Louis, USA) with water and ethylacetate, then adding 2M NaOH, separating the ethylacetate phase and evaporating the ethylacetate, yielding amorphous nicardipine base as a yellow oily-tough substance. Crystalline nicardipine base was prepared by mixing amorphous nicardipine base and isopropanole/diisopropyl ether, adding seed crystals and cooling on an ice bath over night to allow crystallization. The formed crystals were separated by filtration, washed and dried.

후처리

  1. customNicardipine (free base) was prepared
  2. customseparating the ethylacetate phase
  3. customevaporating the ethylacetate

출처 및 근거

ORD 기록
ord-1777db7c9d7c49ecbf704d757e181d1a
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09060986B2

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