Acetic Anhydride → HCID 178526759, 화합물

HRID 2174937노트

반응식

HRID 2174937 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][CH:12]=[CH:13][N+:14]([O-:16])=[O:15])=[C:6]([CH:10]=1)[C:7](O)=[O:8].C([O-])(=O)C.[K+].C(OC(=O)C)(=O)C>>[Br:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:12][C:13]([N+:14]([O-:16])=[O:15])=[C:7]2[OH:8]

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 517044Potassium AcetateHCID 534050555-Bromo-2-(2-nitrovinylamino)benzoic acid2회

생성물 1

HCID 178526759HCID 178526759, 화합물

실험 절차

5-Bromo-2-(2-nitrovinylamino)benzoic acid (Compound A, 87 mmol) and potassium acetate (104 mmol) in acetic anhydride (1185 mmol) were stirred for 3 h at 120° C. The precipitate was filtered, and washed with acetic acid till the filtrate was colorless. It was further washed with water and dried to obtain the title compound. 1H NMR (CDCl3, 500 MHz): δ 9.275 (s, 1H), 8.611-8.615 (d, 1H, J=2 Hz), 8.100-8.118 (d, 1H, J=9 Hz), 8.026-8.048 (dd, 1H, J=8.5 Hz, 2 Hz).

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed with acetic acid till the filtrate
  3. washIt was further washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-6a47060f17eb4b72bd7cefedc29090b8
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09062046B2

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