Hydrochloric Acid → 2-amino-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylic acid

HRID 2175927노트

반응식

HRID 2175927 반응식
[OH-].[Na+].[NH2:3][C:4]1[N:5]=[CH:6][C:7]2[CH:12]([C:13]([O:15]C)=[O:14])[CH2:11][CH2:10][C:8]=2[N:9]=1.Cl>CO>[NH2:3][C:4]1[N:5]=[CH:6][C:7]2[CH:12]([C:13]([OH:15])=[O:14])[CH2:11][CH2:10][C:8]=2[N:9]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86727113methyl 2-amino-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylate

생성물 1

HCID 838618122-amino-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium hydroxide (13.0 mL, 13.0 mmol) was added to a solution of methyl 2-amino-6,7-dihydro-5H-cyclopenta[d]pyrimidine-5-carboxylate (1.10 g, 5.69 mmol) in methanol (21 mL). The resulting mixture was stirred at RT for 1.5 hours. Hydrochloric acid (13 mL, 13.00 mmol) was added. The solvent was evaporated. The residue was purified by chromatography on silica (24 g cartridge) eluting with CH2Cl2:MeOH 95:5 (150 mL) and CH2Cl2:MeOH:AcOH 90:10:1 to afford the title compound.

후처리

  1. customThe solvent was evaporated
  2. customThe residue was purified by chromatography on silica (24 g cartridge)
  3. washeluting with CH2Cl2:MeOH 95:5 (150 mL) and CH2Cl2:MeOH:AcOH 90:10:1

출처 및 근거

ORD 기록
ord-1b8bf926f96d474dab99129277f98c06
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09062070B2

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