Ethanol → 6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinic acid

HRID 2175935

반응식

[CH3:1][C:2]1[N:7]=C(C#N)[C:5]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1.[OH-:15].[Na+].[CH3:17][CH2:18][OH:19]>>[CH3:1][C:2]1[N:7]=[C:17]([C:18]([OH:15])=[O:19])[C:5]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 702Ethanol

HCID 14798Sodium Hydroxide

HCID 68281582HCID 68281582, 화합물

생성물 1

HCID 593637336-methyl-3-(2H-1,2,3-triazol-2-yl)picolinic acid

반응 조건

온도: 100 °C

실험 절차

To a solution of the title compound of Step A (730 mg, 4 mmol) in EtOH (10 mL) was added 4 N NaOH (1 mL, 4 mmol). The mixture was heated at 100° C. for 24 h. The reaction mixture was concentrated in vacuo to a white solid which was used without further purification in subsequent steps.

후처리

concentrationThe reaction mixture was concentrated in vacuo to a white solid which
customwas used without further purification in subsequent steps

출처 및 근거

ORD 기록: ord-eb837fd85db84ac6b61acf6793cc84d7
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09062078B2

연결된 노트

불러오는 중…