3-Methoxyacetophenone → (+-)-1-(3-Methoxyphenyl)ethanol

HRID 2176987

반응식

HRID 2176987 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[CH:5]=1)=[O:3].[BH4-].[Na+].[Cl-].[NH4+]>CO>[CH3:11][O:10][C:6]1[CH:5]=[C:4]([CH:2]([OH:3])[CH3:1])[CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 114603-MethoxyacetophenoneHCID 25517Ammonium ChlorideHCID 4311764Sodium borohydride

생성물 1

HCID 90902(+-)-1-(3-Methoxyphenyl)ethanol수율 86.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3-methoxyacetophenone (3 g; 20 mmol) in methanol (60 mL) is added sodium borohydride (1.13 g; 30 mmol) in four portions over one hour. The reaction is stirred at room temperature overnight, neutralized with saturated ammonium chloride, and extracted with ethyl acetate. The organics are separated, washed with water, and dried over magnesium sulfate. The solvent is removed to give 2.62 grams of 1-(3-methoxyphenyl)-ethanol.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organics are separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed

출처 및 근거

ORD 기록
ord-f34503721ede4d6d87a5b746acb3f354
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067897B2

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