Hydrochloric Acid → HCID 66924212, 화합물

HRID 2177028노트

반응식

HRID 2177028 반응식
[Sn](Cl)Cl.Cl.[Cl:5][C:6]1[CH:24]=[CH:23][C:9]([O:10][CH2:11][C:12]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[C:13]=2[C:14]#[N:15])=[CH:8][C:7]=1[CH3:25].[OH-].[K+]>>[NH2:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:12]([CH2:11][O:10][C:9]2[CH:23]=[CH:24][C:6]([Cl:5])=[C:7]([CH3:25])[CH:8]=2)[C:13]=1[C:14]#[N:15]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 66924453HCID 66924453, 화합물

생성물 1

HCID 66924212HCID 66924212, 화합물수율 88.9%

반응 조건

온도
15 °C

실험 절차

To a cooled (15° C.) and stirred solution of tin (II) chloride (0.37 g, 1.65 mmol) and con. hydrochloric acid (2.0 mL) was added a solution of 2-(4-chloro-3-methylphenoxymethyl)-6-nitrobenzonitrile (100.0 mg, 0.33 mmol). The reaction mixture was slowly warmed to room temperature and stirred for 3 hours. The reaction mixture was poured on to crushed-ice and potassium hydroxide solution, stirred, extracted with dichloromethane, filtered and dried to yield 80 mg of 2-amino-6-(4-chloro-3-methylphenoxymethyl)benzonitrile.

후처리

  1. temperatureThe reaction mixture was slowly warmed to room temperature
  2. additionThe reaction mixture was poured on
  3. stirringstirred
  4. extractionextracted with dichloromethane
  5. filtrationfiltered
  6. customdried

출처 및 근거

ORD 기록
ord-550d240c77d74ce7b7145549e5b1f651
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067897B2

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