Propionic Acid → 2-ethyl-1-phenyl-1H-imidazo[4,5-c]pyridine

HRID 2177625

반응식

HRID 2177625 반응식
[C:1]1([NH:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][C:9]=2[NH2:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15](O)(=O)[CH2:16][CH3:17]>P(Cl)(Cl)(Cl)=O>[CH2:16]([C:17]1[N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2[CH:13]=[CH:12][N:11]=[CH:10][C:9]=2[N:14]=1)[CH3:15]

참가 물질

4

반응물 2

HCID 1032Propionic AcidHCID 105836754-N-phenylpyridine-3,4-diamine

생성물 1

HCID 904095952-ethyl-1-phenyl-1H-imidazo[4,5-c]pyridine수율 19.3%

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

A mixture of N4-phenylpyridine-3,4-diamine (8.0 g, 37.2 mmol), propionic acid (2.7 g, 37.2 mmol) and phosphorous oxychloride (50 mL) was stirred at reflux for 10 h. The reaction was purified by silica gel chromatography using ethyl acetate to afford the product as a solid (1.6 g, 19%).

후처리

  1. temperatureat reflux for 10 h
  2. customThe reaction was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-7cd3cb1fb65b4173a4000af600bf5e42
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09066946B2

연결된 노트

불러오는 중…