Hydrochloric Acid → 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 1-(1,1-dimethylethyl)-5-nitro-

HRID 217956노트

반응식

HRID 217956 반응식
C([O:4][C:5]([C:7]1[C:15]2[C:10](=[N:11][CH:12]=[C:13]([N+:16]([O-:18])=[O:17])[CH:14]=2)[N:9]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:8]=1)=[O:6])CC.[OH-].[Na+].Cl>C(O)C>[C:19]([N:9]1[C:10]2=[N:11][CH:12]=[C:13]([N+:16]([O-:18])=[O:17])[CH:14]=[C:15]2[C:7]([C:5]([OH:6])=[O:4])=[CH:8]1)([CH3:22])([CH3:20])[CH3:21]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 669245181H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 1-(1,1-dimethylethyl)-5-nitro-, propyl ester

생성물 1

HCID 669243961H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 1-(1,1-dimethylethyl)-5-nitro-수율 89.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of 5.00 g (16.38 mmol) of 1-tert-butyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid propyl ester in 50 mL of 95° ethanol, it was added 2M NaOH (50 mL; 100 mmol) under stirring. The mixture was heated to reflux for 1 hour obtaining the complete consumption of the substrate. The resulting solution was cooled to room temperature and concentrated under reduced pressure to a slurry that was diluted with 250 mL of water and washed with 100 mL of a 1:1 mixture of diethyl ether and ethyl acetate. The aqueous layer was treated with 5M HCl (37 mL; 185 mmol) under efficient stirring at room temperature. The precipitate was filtered off, washed twice with 10 mL of water and dried so as to afford 3.84 g of the title compound as a white solid.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 hour
  3. customobtaining
  4. customthe complete consumption of the substrate
  5. concentrationconcentrated under reduced pressure to a slurry that
  6. additionwas diluted with 250 mL of water
  7. washwashed with 100 mL of a 1:1 mixture of diethyl ether and ethyl acetate
  8. stirringunder efficient stirring at room temperature
  9. filtrationThe precipitate was filtered off
  10. washwashed twice with 10 mL of water
  11. customdried so as

출처 및 근거

ORD 기록
ord-2dd0100a063c48ccb5ac3b9f6b2acc81
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198298B2

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