Sodium Hydroxide → HCID 145855861, 화합물

HRID 2181657노트

반응식

HRID 2181657 반응식
Cl.[NH2:2][OH:3].[OH-].[Na+].[CH:6]([C:8]1[O:9][C:10]2[CH:16]=[C:15]([C:17]([O:19][CH3:20])=[O:18])[CH:14]=[CH:13][C:11]=2[CH:12]=1)=O>CCO>[OH:3]/[N:2]=[CH:6]\[C:8]1[O:9][C:10]2[CH:16]=[C:15]([C:17]([O:19][CH3:20])=[O:18])[CH:14]=[CH:13][C:11]=2[CH:12]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 22481722588702-95-8

생성물 1

HCID 145855861HCID 145855861, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Hydroxylamine hydrochloride (153 mg, 2.2 mmol) is free based for 5 min in 2N NaOH (1.1 ml, 2.2 mmol) and added drop-wise to a solution of methyl 2-formyl-1-benzofuran-6-carboxylate (408 mg, 2.0 mmol) in EtOH (6 ml). The reaction is stirred overnight and the volatiles are removed in vacuo. The residue is suspended in water (5 ml) and the slurry is filtered. The cake is dried overnight to afford 399 mg (91%) of E/Z-methyl 2-[(hydroxyimino)methyl]-1-benzofuran-6-carboxylate as a light brown solid. HRMS (FAB) calcd for C11H9NO4+H: 220.0610, found 220.0602 (M+H)+.

후처리

  1. customthe volatiles are removed in vacuo
  2. filtrationthe slurry is filtered
  3. customThe cake is dried overnight

출처 및 근거

ORD 기록
ord-6f7dfc75ebb940b59f710f21d86c1b19
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06894042B2

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