Ammonium Acetate → 1-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181908

반응식

HRID 2181908 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16](=O)[CH3:17].C([O-])(=O)C.[NH4+].C([BH3-])#[N:25].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH2:25])[CH3:17]

참가 물질

5

반응물 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224823721-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethanone

생성물 1

HCID 224823821-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The title compound was prepared from 1-(2′,4′,5-trifluoro-1,1′-biphenyl-2-yl)ethanone (720 mg, 2.9 mmol), anhydrous methanol (10 mL), ammonium acetate (4.44 g, 58 mmol), and sodium cyanoborohydride (362 g, 5.8 mmol) according to the procedure and in the same manner as described in Example 105, step b. The crude amine was immediately used without further purification in Example 114, step c;

후처리

  1. customThe crude amine was immediately used without further purification in Example 114, step c

출처 및 근거

ORD 기록
ord-aedbfb1c67b5452db02693817d12d88e
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06894061B2

연결된 노트

불러오는 중…