Hydrochloric Acid → 5-Ethyl-2-pyridyl-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetic acid

HRID 2187051노트

반응식

HRID 2187051 반응식
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]([CH2:19][C:20]([O:22]CC)=[O:21])[C:11](=[O:18])[C:12]([CH:15]([CH3:17])[CH3:16])([CH3:14])[N:13]=2)=[N:7][CH:8]=1)[CH3:2].[OH-].[Na+].Cl>O1CCCC1>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]([CH2:19][C:20]([OH:22])=[O:21])[C:11](=[O:18])[C:12]([CH:15]([CH3:17])[CH3:16])([CH3:14])[N:13]=2)=[N:7][CH:8]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22450190Ethyl 2-(5-ethyl-2-pyridyl)-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetate

생성물 1

HCID 224501785-Ethyl-2-pyridyl-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A stirred solution of ethyl 2-(5-ethyl-2-pyridyl) -4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetate (2.12 g, 6.41 mmol) in tetrahydrofuran is treated with 2N sodium hydroxide (8 mL). The resulting mixture is stirred at room temperature for 16 hours. After this period, the reaction mixture is concentrated in vacuo to obtain a residue. The residue is acidified with concentrated hydrochloric acid and then extracted with ether. The organic extract is dried over magnesium sulfate, vacuum filtered through diatomaceous earth and concentrated in vacuo to give the title product as a white solid, mp 134-136° C.

후처리

  1. waitAfter this period
  2. concentrationthe reaction mixture is concentrated in vacuo
  3. customto obtain a residue
  4. extractionextracted with ether
  5. extractionThe organic extract
  6. dry with materialis dried over magnesium sulfate, vacuum
  7. filtrationfiltered through diatomaceous earth
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fa78705fcc544fc5a3affb21f807b690
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06407217B1

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