2,4,6-Tribromophenol → HCID 3303004, 화합물

HRID 2189960

반응식

HRID 2189960 반응식
[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Br:9])[C:3]=1[OH:10].Cl[CH2:12][C:13]([CH3:15])=[O:14].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Br:9])[C:3]=1[O:10][CH2:12][C:13](=[O:14])[CH3:15]

참가 물질

6

반응물 4

HCID 14832,4,6-TribromophenolHCID 6228DimethylformamideHCID 6571ChloroacetoneHCID 11430Potassium Carbonate

생성물 1

HCID 3303004HCID 3303004, 화합물수율 97%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
27 °C

실험 절차

A mixture of 5 g 2,4,6-tribromophenol (15 mmol), 1.4 g 1-chloroacetone (15 mmol), 4.16 g anhydrous potassium carbonate (30 mmol) and 20 ml DMF is stirred at 27° C. Completion of the reaction is confirmed by TLC. The reaction mass is diluted with water and extracted with ethylacetate The organic layer is washed with water and brine, dried over anhydrous sodium sulphate and concentrated to obtain 5.6 g 1-(2,4,6-tribromo-phenoxy)-propan-2-one (97%).

후처리

  1. extractionextracted with ethylacetate The organic layer
  2. washis washed with water and brine
  3. dry with materialdried over anhydrous sodium sulphate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-38af585a78e94ac3a9c44895c8a11a23
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324263B2

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