Ethanol → 2,2'-Diamino-4,4'-dibromobiphenyl

HRID 219058

반응식

HRID 219058 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:9]=2[N+:15]([O-])=O)=[C:4]([N+:18]([O-])=O)[CH:3]=1.CCO.[OH-].[Na+]>Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][C:9]=2[NH2:15])=[C:4]([NH2:18])[CH:3]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 100466484,4'-Dibromo-2,2'-dinitro-1,1'-biphenyl

생성물 1

HCID 112215382,2'-Diamino-4,4'-dibromobiphenyl수율 67.5%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

4,4′-dibromo-2,2′-dinitrobiphenyl (6.1 g, 15.17 mmol) was stirred in HCl 30 ml/EtOH 75 ml, Sn powder (7.2 g, 60.68 mmol) was added thereto, and then the reaction mixture was refluxed for 24 hours. Next, the reaction mixture was cooled to room temperature, neutralized with 10% NaOH solution, and then recrystallized in ethanol to obtain 4,4′-dibromo-2,2′-diaminobiphenyl (3.5 g, 67%). MS [M+H] 341.

후처리

  1. additionwas added
  2. temperaturethe reaction mixture was refluxed for 24 hours
  3. customrecrystallized in ethanol

출처 및 근거

ORD 기록
ord-a89cd0efccb94178802fdbdc758cbc25
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198801B2

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