Water → 5-Fluoro-6-(2,3,5-trifluorophenyl)picolinic acid

HRID 2192645노트

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HRID 2192645 반응식
[F:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([F:16])[C:10]=2[F:17])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[Mn]([O-])(=O)(=O)=[O:19].[K+].[OH2:24]>CC(O)(C)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:19])=[O:24])=[N:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([F:16])[C:10]=1[F:17]

참가 물질

5

반응물 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 592265243-Fluoro-6-methyl-2-(2,3,5-trifluorophenyl)pyridine

생성물 1

HCID 592264915-Fluoro-6-(2,3,5-trifluorophenyl)picolinic acid수율 89%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

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온도
90 °C

실험 절차

To a solution of 3-fluoro-6-methyl-2-(2,3,5-trifluorophenyl)pyridine (1.0 equiv.) in water and t-BuOH (2:1, 0.06 M) was added potassium permanganate (10 equiv.) and the solution was heated at 90° C. for 5 hours. Upon cooling to room temperature, the solution was filtered, and the filtrate was concentrated under reduced pressure to yield 5-fluoro-6-(2,3,5-trifluorophenyl)picolinic acid in 89% yield. LC/MS=272.0 (M+H), Rt=0.80 min.

후처리

  1. temperatureUpon cooling to room temperature
  2. filtrationthe solution was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-25e25ec2656a4580afaf04a24f6b1150
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08329732B2

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