3-Chloropropionitrile → 2-(2-Cyanoethyl)isothiourea monohydrochloride

HRID 2196460

반응식

HRID 2196460 반응식
[Cl:1][CH2:2][CH2:3][C:4]#[N:5].[NH2:6][C:7]([NH2:9])=[S:8]>O>[ClH:1].[C:4]([CH2:3][CH2:2][S:8][C:7](=[NH:6])[NH2:9])#[N:5]

참가 물질

4

반응물 2

HCID 109633-ChloropropionitrileHCID 2723790Thiourea

생성물 1

HCID 124175962-(2-Cyanoethyl)isothiourea monohydrochloride

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The 3-chloropropanenitrile (4.32 g, 48.3 mmol) and thiourea (4.04 g, 53.1 mmol) are mixed in 40 ml of water. The mixture is heated to reflux for 3 to 4 hours. The reaction mixture is evaporated and 20 ml of ethanol is added and then evaporated as well. This is repeated three times. After that, 10 ml of methanol and 30 ml of acetone are added and the mixture is stirred for one hour. The crystalline material is filtered and the product is dried under high vacuum overnight to obtain S-(2-cyanoethyl)isothiourea hydrochloride.

후처리

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 3 to 4 hours
  3. customThe reaction mixture is evaporated
  4. addition20 ml of ethanol is added
  5. customevaporated as well
  6. additionAfter that, 10 ml of methanol and 30 ml of acetone are added
  7. filtrationThe crystalline material is filtered
  8. customthe product is dried under high vacuum overnight

출처 및 근거

ORD 기록
ord-a0ace451e99f48af951657833e57eeeb
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338454B2

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