Hydrochloric Acid → HCID 19930842, 화합물

HRID 21984노트

반응식

HRID 21984 반응식
[O:1]=[C:2]1[CH:15]([C:16]([O:18]CC)=[O:17])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH:4]([C:21]([O:23]CC)=[O:22])[NH:3]1.[OH-].[Na+].Cl>C(O)C>[O:1]=[C:2]1[CH:15]([C:16]([OH:18])=[O:17])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH:4]([C:21]([OH:23])=[O:22])[NH:3]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19930817Diethyl 2-oxo-1-azacyclotetradecane-3,14-dicarboxylate

생성물 1

HCID 19930842HCID 19930842, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Diethyl 2-oxo-1-azacyclotetradecane-3,14-dicarboxylate (1.14 g, 3.2 mmol; mixture of both diastereomers) is dissolved in ethanol (32.0 mL). Sodium hydroxide (9.6 mL of a 1N aqueous solution, 9.6 mmol) is added dropwise, and the solution is stirred at room temperature for 3 hours. The reaction is then acidified to pH 3 with 1N hydrochloric acid, and partitioned between ethyl acetate and water. The aqueous phase is extracted several times with ethyl acetate, the combined organic layers are dried (Na2SO4), and the solvent is evaporated to give both diastereomers of 2-oxo-1-azacyclotetradecane-3,14-dicarboxylic acid.

후처리

  1. additionmixture of both diastereomers)
  2. custompartitioned between ethyl acetate and water
  3. extractionThe aqueous phase is extracted several times with ethyl acetate
  4. dry with materialthe combined organic layers are dried (Na2SO4)
  5. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-d2ee70d357da4568a932be1e31fddb1f
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05426103

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