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Hydrochloric Acid → 4-(5-(3-Cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylbutanamide

HRID 2201212
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HRID 2201212 반응식
C(P1(=O)OP(CCC)(=O)OP(CCC)(=O)O1)CC.Cl.CC[N:22]([CH:26](C)C)C(C)C.[C:29]([C:31]1[CH:32]=[C:33]([C:37]2[N:38]([CH2:50][CH2:51][CH2:52][C:53]([O-])=[O:54])[CH:39]=[C:40]3[C:45]=2[C:44](=[O:46])[N:43]([CH3:47])[C:42](=[O:48])[N:41]3[CH3:49])[CH:34]=[CH:35][CH:36]=1)#[N:30].[Li+].CN([CH:60]=[O:61])C>>[C:29]([C:31]1[CH:32]=[C:33]([C:37]2[N:38]([CH2:50][CH2:51][CH2:52][C:53]([N:22]([O:61][CH3:60])[CH3:26])=[O:54])[CH:39]=[C:40]3[C:45]=2[C:44](=[O:46])[N:43]([CH3:47])[C:42](=[O:48])[N:41]3[CH3:49])[CH:34]=[CH:35][CH:36]=1)#[N:30]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 111923Propylphosphonic anhydrideHCID 86723451Lithium 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoate

생성물 1

HCID 86723452
4-(5-(3-Cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylbutanamide

실험 절차

T3P® (31.3 ml, 52.6 mmol) was added dropwise to a solution of N,O-dimethyllhydroxylamine hydrochloride (2.70 g, 27.6 mmol), DIPEA (18.39 ml, 105 mmol) and lithium 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoate (9.8 g, 26.3 mmol) in DMF (263 mL). The mixture was stirred at room temperature for 40 minutes and quenched with water (250 mL). The resultant precipitate was collected by filtration under reduced pressure to afford the title compound.

후처리

  1. customquenched with water (250 mL)
  2. filtrationThe resultant precipitate was collected by filtration under reduced pressure

출처 및 근거

ORD 기록
ord-f03ca06b77654e51b53e50b8de2d2f4e
출처 데이터셋
uspto-grants-2016_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09359381B2

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