Acetic Anhydride → N-(2-Chloro-5-methoxyphenyl)acetamide
반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:3]=1[NH2:4].[C:11](OC(=O)C)(=[O:13])[CH3:12]>CC(O)=O>[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:3]=1[NH:4][C:11](=[O:13])[CH3:12]참가 물질
4
실험 절차
To a solution of 10.59 g of 2-chloro-5-methoxyaniline in 50 mL of AcOH were added dropwise at 0° C. 6.8 mL of acetic anhydride. The reaction mixture was allowed to warm up to rt, stirred for 6 h and concentrated in vacuo. The crude product was purified by CC using EtOAc/heptane 1/3 to yield 13.0 g of N-(2-chloro-5-methoxy-phenyl)-acetamide as white solid.
후처리
- concentrationconcentrated in vacuo
- customThe crude product was purified by CC
출처 및 근거
- ORD 기록
- ord-6bdd3efc020643ea87201df1f991d82f
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08202885B2
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