Benzoyl chloride → HCID 57555405, 화합물

HRID 220811

반응식

HRID 220811 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].C(=O)(O)[O-].[Na+].[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CCOC(C)=O.O>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:3]([OH:9])[CH:4]=1

참가 물질

6

반응물 3

HCID 7412Benzoyl chlorideHCID 915912-Amino-5-chlorophenolHCID 516892Sodium Bicarbonate

생성물 1

HCID 57555405HCID 57555405, 화합물수율 82.8%

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

2-Amino-5-chlorophenol (1.45 g, 10 mmol) was dissolved in EtOAc (30 ml) and water (20 ml). Sodium bicarbonate (1.25 g, 15 mmol) then benzoyl chloride (1.42 g, 10 mmol) were added and the mixture was stirred at room temperature for 1 h. The layers were partitioned and the organic layer was washed with brine, dried and concentrated in vacuo. The residue was triturated with di-ethyl ether to yield the title compound (2.05 g, 82%).

후처리

  1. customThe layers were partitioned
  2. washthe organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated in vacuo
  5. customThe residue was triturated with di-ethyl ether

출처 및 근거

ORD 기록
ord-10d36463adb94f57853f5b42f12f0bdb
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202858B2

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