Hydrochloric Acid → 5-Bromo-2,4-dimethylbenzoic acid

HRID 2208747

반응식

HRID 2208747 반응식
[OH-].[Na+].[Br:3]Br.[CH3:5][C:6]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].Cl>O>[Br:3][C:12]1[C:13]([CH3:15])=[CH:14][C:6]([CH3:5])=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 118972,4-Dimethylbenzoic acidHCID 14798Sodium HydroxideHCID 24408Bromine

생성물 1

HCID 5557655-Bromo-2,4-dimethylbenzoic acid수율 65%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To the stirred solution of NaOH (60 g) in water (1152 ml) was added bromine (36 ml) dropwise at 0° C. and stirred the reaction mixture for 45 min. at same temperature. 2,4-dimethylbenzoic acid (12 g, 79.9 mmol) was added in above reaction mixture at 0° C. portion wise and stirred the reaction at room temperature for 3 h. After completion of reaction of reaction (TLC) reaction mixture was acidified using conc. HCl, solid was filtered through Buchner funnel and wash with water and dried to afford the desired compound (12 g, 65%) which was used without further purification.

후처리

  1. stirringstirred
  2. customthe reaction at room temperature for 3 h
  3. customAfter completion of reaction of reaction (TLC) reaction mixture
  4. filtrationwas filtered through Buchner funnel
  5. washwash with water
  6. customdried

출처 및 근거

ORD 기록
ord-00b87eac2bba4f85bd7b141eb07d33cf
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09376422B2

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