Hydrochloric Acid → HCID 10487762, 화합물
반응식
[S:1]1(=[O:12])(=[O:11])[C:6]2[CH:7]=[CH:8][CH:9]=[N:10][C:5]=2[NH:4][CH:3]=[N:2]1.[BH4-].[Na+].Cl>O>[S:1]1(=[O:11])(=[O:12])[C:6]2[CH:7]=[CH:8][CH:9]=[N:10][C:5]=2[NH:4][CH2:3][NH:2]1참가 물질
5
실험 절차
1 g of 4H-pyrido[2,3-e][1,2,4]thiadiazine 1,1- dioxide is suspended in 30 cm3 of water. A solution of 0.83 g of NaBH4 in 5 cm3 of water is added to the suspension. After stirring for 15 minutes at ambient temperature, the pH of the solution is adjusted to 6.5-7 using dilute HCl. The precipitate obtained is filtered, washed with water and dried. The dried compound is dissolved in 200 cm3 of dichloromethane. The possible insoluble material is removed by filtration. The filtrate is treated with an equal volume of petroleum ether (40°-60° C.) and placed at +4° C. overnight. The crystals obtained are collected on a filter and dried.
후처리
- customThe precipitate obtained
- filtrationis filtered
- washwashed with water
- customdried
- dissolutionThe dried compound is dissolved in 200 cm3 of dichloromethane
- customThe possible insoluble material is removed by filtration
- additionThe filtrate is treated with an equal volume of petroleum ether (40°-60° C.)
- waitplaced at +4° C. overnight
- customThe crystals obtained
- customare collected on
- filtrationa filter
- customdried
출처 및 근거
- ORD 기록
- ord-f42d5bf4ac4a429ea70bd9c6d78c5b8a
- 출처 데이터셋
- uspto-grants-1995_10
- 특허 번호
- US05459138
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