Hydrochloric Acid → HCID 86749040, 화합물

HRID 2210476노트

반응식

HRID 2210476 반응식
[OH:1][N:2]=[C:3]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:4]([NH:6][CH:7]([C:13]([O:15]CC)=[O:14])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:5].[OH-].[Na+].O.Cl>C(O)C>[CH2:11]([O:10][C:8](=[O:9])[CH:7]([NH:6][C:4](=[O:5])[C:3](=[N:2][OH:1])[CH2:18][CH:19]([CH3:20])[CH3:21])[C:13]([OH:15])=[O:14])[CH3:12]

참가 물질

6

반응물 4

HCID 313Hydrochloric Acid2회HCID 962WaterHCID 14798Sodium HydroxideHCID 86747153HCID 86747153, 화합물

생성물 1

HCID 86749040HCID 86749040, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In to a solution of 29.19 g of diethyl N-(2-hydroxyimino-4-methylpentanoyl)aminomalonate in 200 ml of ethanol was added 2.8 g of sodium hydroxide and 200 ml of water, then the mixture was stirred at room temperature for 4 hours. The reaction mixture was neutralized with 10% hydrochloric acid, then concentrated. To the residue thus obtained was added 10% hydrochloric acid to make it acidified, then it was extracted with ethyl acetate, and the ethyl acetate layer was washed with water, an aqueous solution saturated with sodium chloride in this order, then dried with magnesium sulfate. The solvent was removed by distillation to obtain 23.0 of N-(2-hydroxyimino-4-methylpentanoyl)aminomalonic acid monoethyl ester.

후처리

  1. concentrationconcentrated
  2. customTo the residue thus obtained
  3. extractionit was extracted with ethyl acetate
  4. washthe ethyl acetate layer was washed with water
  5. dry with materialan aqueous solution saturated with sodium chloride in this order, then dried with magnesium sulfate
  6. customThe solvent was removed by distillation

출처 및 근거

ORD 기록
ord-ef0d970507764459ad3add25e2ba9775
출처 데이터셋
uspto-grants-1995_10
특허 번호
US05459142

반응 노트

불러오는 중…