Sodium Azide → 5-(azidomethyl)-2,4(1H,3H)-pyrimidinedione

HRID 2211818

반응식

HRID 2211818 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].Cl[CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1>CS(C)=O>[N:1]([CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1)=[N+:2]=[N-:3]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 2361255-(Chloromethyl)uracil

생성물 1

HCID 219630275-(azidomethyl)-2,4(1H,3H)-pyrimidinedione수율 98.5%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Sodium azide (0.6 g, 9.34 mmol) was added to a solution of 5-(chloromethyl)-2,4(1H,3H)-pyrimidinedione (0.3 g, 1.67 mmol) in DMSO (5 ml) under nitrogen at room temperature. The reaction was stirred for 2 h then partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate and concentrated to give the 5-(azidomethyl)-2,4(1H,3H)-pyrimidinedione (0.275 g, 98%) as a yellow solid.

후처리

  1. customthen partitioned between ethyl acetate and water
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-22f7f1367d0f4603af5b503bf3ddbb77
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07101883B2

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