Hydrochloric Acid → 2-oxo-2-((10S,13S,16R,17S)-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)ethyl acetate

HRID 221196

반응식

HRID 221196 반응식
[C:1]([O:4][CH2:5][C:6](=[C:12]1[C@:28]2([CH3:29])[CH:15]([CH:16]3[C:25](=[CH:26][CH2:27]2)[C@:24]2([CH3:30])[C:19](=[CH:20][C:21](=[O:31])[CH:22]=[CH:23]2)[CH2:18][CH2:17]3)[CH2:14][C@H:13]1[CH3:32])[O:7][Si](C)(C)C)(=[O:3])[CH3:2].Cl.C(=O)(O)[O-].[K+]>C(OCC)(=O)C>[C:1]([O:4][CH2:5][C:6](=[O:7])[C@@H:12]1[C@:28]2([CH3:29])[CH:15]([CH:16]3[C:25](=[CH:26][CH2:27]2)[C@:24]2([CH3:30])[C:19](=[CH:20][C:21](=[O:31])[CH:22]=[CH:23]2)[CH2:18][CH2:17]3)[CH2:14][C@H:13]1[CH3:32])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516893Potassium BicarbonateHCID 672831772-((10S,13S,16R)-10,13,16-trimethyl-3-oxo-7,8,12,13,15,16-hexahydro-3H-cyclopenta[a]phenanthren-17(6H,10H,14H)-ylidene)-2-(trimethylsilyloxy)ethyl acetate

생성물 1

HCID 592717402-oxo-2-((10S,13S,16R,17S)-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)ethyl acetate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The crude product from step 1 is dissolved in ethyl acetate, and slurried with aqueous 1N HCl until hydrolysis is complete. The aqueous acid is neutralized with aqueous potassium bicarbonate, and the ethyl acetate phase is dried, filtered, and concentrated to a semi-solid.

후처리

  1. dry with materialthe ethyl acetate phase is dried
  2. filtrationfiltered
  3. concentrationconcentrated to a semi-solid

출처 및 근거

ORD 기록
ord-ad2e6a2319ef470294a0d3ec4ae92f0f
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207151B2

연결된 노트

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