Potassium Carbonate → cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline

HRID 2214753

반응식

HRID 2214753 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([O:21][CH3:22])=[C:10]([N:13]3[CH2:18][C@H:17]([CH3:19])[NH:16][C@H:15]([CH3:20])[CH2:14]3)[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.C([O-])([O-])=O.[K+].[K+]>Cl>[CH3:20][C@H:15]1[NH:16][C@@H:17]([CH3:19])[CH2:18][N:13]([C:10]2[CH:11]=[C:12]3[C:7]([CH2:6][CH2:5][NH:4]3)=[CH:8][C:9]=2[O:21][CH3:22])[CH2:14]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 69664906cis-1-Acetyl-6-(3,5-dimethylpiperazin-1-yl)-5-methoxyindoline

생성물 1

HCID 11265480cis-6-(3,5-Dimethylpiperazin-1-yl)-5-methoxyindoline수율 107.1%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A stirred solution of D2 (1.6 g, 5 mmole) in 2M HCl acid (50 ml) was heated under reflux for 2 h, then allowed to cool, basified with K2CO3 and extracted with DCM. The extract was dried (Na2SO4) and concentrated under vacuum to afford the title compound as a pale orange solid (1.4 g, 100%). MH+ 276.

후처리

  1. temperatureunder reflux for 2 h
  2. temperatureto cool
  3. extractionextracted with DCM
  4. dry with materialThe extract was dried (Na2SO4)
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-7ddca317ee804d899f4ca913d4e9e9ca
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109201B2

연결된 노트

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