Cyanogen Bromide → 2-Aminobenzimidazole

HRID 221519

반응식

HRID 221519 반응식
[N:1]#[C:2]Br.[NH2:4][C:5]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][C:6]=1OC.[OH-].[Na+]>CCO.O>[NH2:1][C:2]1[NH:4][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=2[N:11]=1

참가 물질

6

반응물 3

HCID 10476Cyanogen BromideHCID 14798Sodium HydroxideHCID 1842683-Methoxybenzene-1,2-diamine

생성물 1

HCID 136242-Aminobenzimidazole

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Cyanogen bromide (7.05 mmol, 0.74 g) was added to a solution of 2,3-diaminoanisole (4.7 mmol, 0.65 g) in EtOH (10 mL) and the reaction was stirred at room temperature for 14 h. The reaction was diluted with H2O and then basified (pH>12) using 4 M NaOH. The aqueous layer was extracted with CH2Cl2. The organic phase was then separated and washed with brine and then dried over MgSO4 and then concentrated to provide 2-aminobenzimidazole 37b.

후처리

  1. extractionThe aqueous layer was extracted with CH2Cl2
  2. customThe organic phase was then separated
  3. washwashed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4dd7d82b92d54646aeddc463d3d6f37d
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207173B2

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