Hydrochloric Acid → Sodium Chloride
반응식
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([O:12][CH3:13])=[CH:7][N:6]=1)=[O:4].[OH-].[Na+:15].[ClH:16].C1(C)C=CC=CC=1>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[C:8]([O:12][CH3:13])[N:9]=1.[Cl-:16].[Na+:15]참가 물질
7
실험 절차
To a solution of 200 mg (1.092 mmol) 3-amino-5-methoxy-pyrazine-2-carboxylic acid methyl ester in 4 ml THF was added 1.20 ml (1.20 mmol) 1N sodium hydroxide and the mixture was stirred at room temperature for 29 h. To the mixture were added 1.09 ml (1.09 mmol) 1N HCl after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with sodium chloride as colorless solid. The mixture was used for coupling reactions without further purification.
후처리
- additionwas added
- customthe solvents were evaporated
출처 및 근거
- ORD 기록
- ord-3e03590e813e4d4a9740175cc56deb71
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08207164B2
반응 노트
불러오는 중…