Water → ((4-Cyclohexylphenoxy)methyl)oxirane

HRID 221948

반응식

HRID 221948 반응식
[CH2:1]1[O:3][C@H:2]1[CH2:4]Cl.[CH:6]1([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>C(#N)C>[CH:6]1([C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:4][CH:2]3[CH2:1][O:3]3)=[CH:16][CH:17]=2)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1

참가 물질

6

반응물 4

HCID 962WaterHCID 10796Cesium carbonateHCID 143274-CyclohexylphenolHCID 2734062(-)-Epichlorohydrin

생성물 1

HCID 5743581((4-Cyclohexylphenoxy)methyl)oxirane

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a mixture of R-epichlorohydrin (9.8 g, 106 mmol) and 4-cyclohexylphenol (3.73 g, 21.2 mmol) in acetonitrile (40 ml) was added cesium carbonate (6.9 g, 21.2 mmol). The mixture was heated at reflux for 3 hours. The reaction mixture was cooled, poured into water (100 mL) and extracted twice with EtOAc. The organic phases were combined and washed with water, brine, dried (Na2SO4), concentrated and dried under high vacuum overnight to give the title compound.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 3 hours
  3. temperatureThe reaction mixture was cooled
  4. extractionextracted twice with EtOAc
  5. washwashed with water, brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated
  8. customdried under high vacuum overnight

출처 및 근거

ORD 기록
ord-d3037173a1b8480bbbcf4512227dd842
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207181B2

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