N-cyclohexyl-N-thiazol-2-yl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetamide → N-cyclohexyl-N-thiazol-2-yl-5-methoxy-2-methylindole-3-acetamide

HRID 2219671

반응식

HRID 2219671 반응식
[CH:1]1([N:7]([C:32]2[S:33][CH:34]=[CH:35][N:36]=2)[C:8](=[O:31])[CH2:9][C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([O:19][CH3:20])[CH:17]=3)[N:12](C(=O)C3C=CC(Cl)=CC=3)[C:11]=2[CH3:30])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>ClCCl.CO.[OH-].[Na+]>[CH:1]1([N:7]([C:32]2[S:33][CH:34]=[CH:35][N:36]=2)[C:8](=[O:31])[CH2:9][C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([O:19][CH3:20])[CH:17]=3)[NH:12][C:11]=2[CH3:30])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

5

반응물 1

HCID 58618036N-cyclohexyl-N-thiazol-2-yl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetamide

생성물 1

HCID 69312574N-cyclohexyl-N-thiazol-2-yl-5-methoxy-2-methylindole-3-acetamide

시약·촉매·용매 3

HCID 887Methanol용매HCID 6344Dichloromethane용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 2.42 g (0.0045 mol) of N-Cyclohexyl-N-thiazol-2-yl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetamide in 2.4 mL of dichloromethane, 48 mL of methanol and 24 mL of 1N aqueous NaOH solution was stirred at rt for 90 min. During this time, the title compound formed as a precipitate. It was filtered, washed with water and dried.

출처 및 근거

ORD 기록
ord-6ad97f6b63e94092b3ac9cc48e6d7a92
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07414067B2

연결된 노트

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