Carbon tetrabromide → Methyl 4'-(2-bromoethoxy)-3-(isopropylthio)-4-biphenylcarboxylate

HRID 2220402노트

반응식

HRID 2220402 반응식
O[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([O:19][CH3:20])=[O:18])=[C:13]([S:21][CH:22]([CH3:24])[CH3:23])[CH:12]=2)=[CH:7][CH:6]=1.[Br:25]C(Br)(Br)Br.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[Br:25][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([O:19][CH3:20])=[O:18])=[C:13]([S:21][CH:22]([CH3:24])[CH3:23])[CH:12]=2)=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 69102146Methyl 4'-(2-hydroxyethoxy)-3-(isopropylthio)-4-biphenylcarboxylate

생성물 1

HCID 69103348Methyl 4'-(2-bromoethoxy)-3-(isopropylthio)-4-biphenylcarboxylate수율 96.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl 4′-(2-hydroxyethoxy)-3-(isopropylthio)-4-biphenylcarboxylate (124 mg) and tetrabromomethane (285 mg) in tetrahydrofuran (1.86 ml) was added triphenylphosphine (207 mg) and stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo, and the residue was purified with silica gel column chromatography to give methyl 4′-(2-bromoethoxy)-3-(isopropylthio)-4-biphenylcarboxylate (142 mg).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was purified with silica gel column chromatography

출처 및 근거

ORD 기록
ord-523a535b547247b7bd71b4ada36b7b3d
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07417060B2

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